Damaging Link Dietary Supplements and Your Liver

Bodybuilding and weight loss supplements may help you look better, but with some of these supplements there’s an ugly tradeoff: a very real risk of liver damage. Using data from a national registry, researchers found that herbal and dietary supplements were implicated in 18 per cent of liver injury cases caused or suspected of being caused by drugs or supplements from 2003 to 2011.
Bodybuilding and weight loss supplements were by far the biggest offenders, linked to 34 per cent and 26 per cent of 93 cases studied, respectively, says researcher Victor J. Navarro, MD, a professor of medicine, pharmacology, and experimental therapeutics at Thomas Jefferson University in Philadelphia. Still, the study is not meant to scare people, Navarro says. Many supplements are beneficial to your health, he says, ticking off a long list that includes calcium and vitamin D supplements and multivitamins made by reputable companies. Plus, the absolute risk of any one person developing supplement-associated liver injury may be very small, he says.

THE LIVER’S IMPORTANCE
The liver is the largest gland of the body, weighing about 1.5 kg. It could just about be called your fountain of youth or your lifeline. You will look as old or as young as your liver is clean it figures into anti-aging big time. The liver can do 500 functions – that’s some multitasking! This is one powerful organ, the one organ in the body that is capable of regenerating itself. Unfortunately, in this day and age with all the pollution in the air and food, the liver is being asked to take on TOO MUCH. There’s hardly a person alive that would not benefit from a liver cleanse. Why? The liver helps clean the blood, and helps remove all the pollutants before they get all over our bodies. The liver removes dead or damaged blood cells from circulation, just like the Government would remove damaged money from circulation. Why is this important, you ask? Well, because the blood nourishes every body system. If your blood is unhealthy, you will be too.

Drug-Linked Liver Injury a Major Problem
Liver damage from medication is one common reason that drugs are pulled off the market. And certain supplements have been linked to drug-associated liver injury, Navarro says. Many people take herbal and dietary supplements, which do not require a prescription and are not tightly regulated by laws. Yet there’s a lack of solid information about their side effects, including liver-related toxicities, Navarro says.
Researchers asked people what supplements they were taking. Most still had the products at home and brought them in for testing to determine whether they actually contained what the labels said they did, among other factors. People also underwent a battery of exams with the goal of better understanding supplement-associated liver ills.
Bodybuilding, Weight Loss Supplements
Different supplements were associated with different types of liver injury, Navarro says. “We’re not saying they all caused liver injury. They did appear to have the potential to cause harm and people need to recognise that,” he says.
Bodybuilding supplements were linked to jaundice  exclusively in men that can last a month or more, Navarro says. And if the word jaundice brings to mind the typically harmless and temporary yellow tint of newborns skin and eyes, think again. “Bodybuilding products left some men bright yellow and itching like crazy with a jaundice so severely debilitating they couldn’t work. Their quality of life deteriorated,” Navarro says. More than half of the 29 men taking these supplements had to be hospitalised in the study.
Weight loss supplements were linked to even worse damage inflammation of the liver that in some cases could have been fatal without a liver transplant, he says. In the study, 12 per cent of the 17 people taking weight loss products needed a transplant. In about half of the cases involving bodybuilding supplements and 41 per cent of cases involving weight loss supplements, the researchers concluded that the products “definitely” were the cause of drug-induced liver injury. The people weren’t taking any other medication, Navarro says.
Other types of supplements that were implicated in 10 per cent to 14 per cent of cases were immune-boosters, cough and cold products, anddepression and anxiety products.
Involve Doctor in Conversation
Donald M. Jensen, MD, professor of medicine and director of the Center for Liver Diseases at the University of Chicago Medical Center, says it’s important to tell your doctor if you are thinking about taking supplements, as they can offer guidance about which ones may be beneficial. In some cases, they may want to monitor your liver enzymes, he says. Jensen was not involved with the work.
Also, “patients need to be label readers,” he says. “You can’t just assume that everything out there is safe; there are [products] out there that can be potentially damaging.” Duffy MacKay, ND, vice president of scientific and regulatory affairs at the Council for Responsible Nutrition (CRN), said that liver damage in people on supplements is likely due to “spiking” with undisclosed ingredients.
With bodybuilding and weight loss products in particular, MacKay says, he is concerned about the addition of steroid or steroid-like compounds. Steroids and their cousins can help people to build muscle, and they have been linked to liver injury, he says.

Reviewed by Laura J. Martin, MD. These findings were presented at a medical conference. They should be considered preliminary, as they have not yet undergone the “peer review” process, in which outside experts scrutinse the data prior to publication in a medical journal.

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